Main information about Nolvadex
Nolvadex is used for the treatment of the malignant tumor stimulated by estrogens. It contains a strong antiestrogen Tamoxifene.
Estrogenic processes are located in some organs: uterus, vagina, urinary tract, breast, liver, hypothalamus, and pituitary gland. Thesereceptorsregulateaproductionofestrogen. In case of the formation of the cancerous tumors, estrogens may stimulate a development of tumor, so that a process of the production of the cancerous cells is accelerated.
Nolvadex blocks estrogenic receptors in the target organs and malignant tumors, so that a process of the development of the cancerous tumor is retarded.
Using Nolvadex stops producing the cancerous cells stimulated by estrogen. Tumor goes to the latent form and may be in this state within several years. A therapy of Nolvadex reduces an importance of the surgical intervention in the treatment of the malignant tumors and helps to improve the life quality of patients with cancer.
Nolvadex may be used in the treatment of the malignant tumors in the organs where the action of estrogens is more intense:
- Mammary cancer
- Breast cancer in men
- Kidney cancer
- Endometrial cancer
- Prostate Cancer
- Soft tissue sarcoma
Use and dose of Nolvadex
To treat breast cancer, patients are recommended to take a tablet of Nolvadex 20 mg 1-2 times per day. If the side effects are absent, a one-time dose of Nolvadex may be increased up to 40 mg.
To treat cancer of kidneys or endometrium, patients are also prescribed a tablet of Nolvadex 20-30 mg 1-2 times per day.
A therapeutic effect is kept only during the prolonged treatment. The action of a tablet of Nolvadex 20 mg lasts for 12 to 20 hours, and therefore if you forgot to take a dose, there is an expectancy of the restored activity of the estrogenic receptors and a reduction of the treatment efficiency.
The treatment of tumors may take 1 to 5 years depending on the sensitivity to Nolvadex. In case of the prolonged treatment, a tolerance of Nolvadex may be developed. If a growth of the cancerous cells is restored during the medical study because of the use of Nolvadex, the treatment is terminated.
Recommendations for the use
- It is necessary to regularly being followed up by a doctor during the treatment, and a growth of the tumor should be followed
- Before starting the treatment, have a gynecological examination and eliminate a chance of the pregnancy
- Using Nolvadex it is necessary to regularly take blood tests and check the rates of the blood coagulation, state of blood (leukocytes, platelets), and liver functions
- The treatment is cancelled during the formation of thrombus
Side effect
The side effects appeared as a result of the use of Nolvadex may be caused by the changed work of the estrogenic receptors. Every 4th patient taking Nolvadex has side effects: high body temperature, low appetite, nausea, dry skin, vaginal discharges, low potency/libido.
The side effects often pass in the light form and completely disappear during the prolonged treatment. If the side effects of Nolvadex bring discomfort within a long time, consult a physician.
